Proteinopathy arises from accumulation of misfolded and toxic proteins such as β-amyloid or α-synuclein, disrupting neuron structure and key cellular function. We are developing potent therapeutic molecules that bind and remove these disease-causing proteins. As a result, the therapy will alleviate neurotoxicity and slow down or halt neuron death.

Blood carrying oxygen and nutrients to the brain is essential for neuron health. Reduced blood flow and leaky blood-brain barriers are common events in neurodegeneration such as Alzheimer’s disease and vascular dementia. We are developing first-in-class molecules that repair vascular defects, restoring healthy blood flow to the brain.

Our body’s immune cells react to intrinsic cellular changes or foreign pathogens by launching appropriate responses. In neurodegenerative diseases, too little or too much response from brain microglia or periphery immune cells aggravates neuron damage and loss. Our approach is to promote protective immune response while curb harmful pro-inflammatory cues with potent and selective therapeutic molecules.