Proteopathy arises from misfolded and toxic proteins such as β-amyloid or α-synuclein. We are developing very potent therapeutic molecules that bind and remove these toxic proteins. As a result, the therapy will alleviate proteopathy and slow down or halt neuron death.

Inflammation is a process where immune cells react to intrinsic cellular changes or damages caused by foreign pathogens. In neurodegenerative diseases, maladaptive inflammation aggravates neuron damage and loss.  Our approach is to curb pro-inflammatory cues (also proteins) with potent and selective therapeutic molecules.

Lysosomal Dysfunction is a common causality in both neurodegenerative diseases such as PD and a host of rare diseases known as lysosomal storage diseases (LSDs). Lysosome is a key cellular organelle that functions as a waste management system by removing intracellular and extracellular debris. One of our strategies is to normalize enzymes central to lysosome function.