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A growing portfolio of novel medicines addressing targets and pathways critical in neurodegenerative and other CNS disorders

What is Neurodegeneration?

Brain diseases affecting mind and body, represent a major societal burden impacting patients of all age, gender, and ethnicity. SciNeuro is dedicated to developing medicines for neurological diseases with a specific focus on neurodegenerative diseases in which the structure and function of neurons are progressively damaged and lost. As a result, patients lose their natural ability to move, speak, remember, or think. Neurodegeneration can present in various forms, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), two common neurodegenerative diseases affecting more than 65 million patients worldwide, as well as rare conditions like amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA).

Pipeline Strategy

In recent years, the rapid progress of human genetic, genomic, and biomarker studies have revealed molecular and pathological culprits of neurodegeneration, nominating promising therapeutic targets.

More research now provides scientific details revealing drivers of neurodegeneration in key related pathways highlighting proteinopathy, neurovascular inflammation, and immune response. We have developed a focused portfolio to target each of these mechanisms:

Clear misfolding proteins through immune therapy

Proteinopathy arises from accumulation of misfolded and toxic proteins such as β-amyloid or α-synuclein, disrupting neuron structure and key cellular function.

Protect / repair vasculature by reducing inflammation

Reduced blood flow and leaky blood-brain barriers associated with neurovascular inflammation are common events in neurodegeneration such as Alzheimer’s disease and vascular dementia.

Restore homeostatic immune response

Immune cells react to intrinsic cellular changes or foreign pathogens by launching appropriate responses. Too little or too much response from brain or peripheral immune cells aggravates neuron damage and loss.